Ancient Ubiquitous Protein 1 antibody (AA 77-399) (Biotin)

Catalog No. ABIN7968388

This Rabbit Polyclonal antibody specifically detects Ancient Ubiquitous Protein 1 in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for Ancient Ubiquitous Protein 1 antibody (AA 77-399) (Biotin) (ABIN7968388)

Target: Ancient Ubiquitous Protein 1 (Aup1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ancient Ubiquitous Protein 1 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Ancient Ubiquitous Protein 1 Antibody (Biotin)

Binding Specificity: AA 77-399

Purpose: Anti-AUP1 Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human AUP1 recombinant protein (Position: A77-R399).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Ancient Ubiquitous Protein 1

Target: Ancient Ubiquitous Protein 1 (Aup1)

Alternative Name: AUP1

Background:

Background: Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene. The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants.

Gene Full Name: AUP1 lipid droplet regulating VLDL assembly factor

Gene ID: 550

UniProt: Q9Y679