Angiopoietin 1 antibody (AA 16-350) (Fluoro488)

Catalog No. ABIN7968467

The Rabbit Polyclonal anti-Angiopoietin 1 antibody is suitable to detect Angiopoietin 1 in samples from Human. It has been validated for FACS.

Quick Overview for Angiopoietin 1 antibody (AA 16-350) (Fluoro488) (ABIN7968467)

Target: Angiopoietin 1 (ANGPT1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Angiopoietin 1 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-Angiopoietin 1 Antibody (Fluoro488)

Binding Specificity: AA 16-350

Purpose: Anti-Angiopoietin 1/ANGPT1 Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human Angiopoietin 1 shares 96% amino acid (aa) sequence with both mouse,rat Angiopoietin 1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Angiopoietin 1 recombinant protein (Position: H16-N350). Human Angiopoietin 1 shares 96% amino acid (aa) sequence with both mouse and rat Angiopoietin 1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Angiopoietin 1

Target: Angiopoietin 1 (ANGPT1)

Alternative Name: ANGPT1

Background:

Background: Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1. Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. Angiopoietin 1 is mapped to 8q23.1. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

Gene Full Name: angiopoietin 1

Sequence Similarities: Contains 1 fibrinogen C-terminal domain.

Gene ID: 284

UniProt: Q15389

Pathways: RTK Signaling, Glycosaminoglycan Metabolic Process