RPS6KB2 antibody (pThr228)

Catalog No. ABIN747233

The Rabbit Polyclonal anti-RPS6KB2 antibody has been validated for FACS. It is suitable to detect RPS6KB2 in samples from Human, Mouse, Rat, Cow, Dog, Pig and Chicken.

Quick Overview for RPS6KB2 antibody (pThr228) (ABIN747233)

Target: RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPS6KB2 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Product Details anti-RPS6KB2 Antibody

Binding Specificity: pThr228

Cross-Reactivity: Cow, Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human p70 S6 Kinase Beta around the phosphorylation site of Thr228

Isotype: IgG

Application Details

Application Notes: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for RPS6KB2

Target: RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2))

Alternative Name: p70 S6 Kinase Beta

Background:

Synonyms: P70 S6 Kinase beta phospho Thr228, P70 S6 Kinase beta T228, p-P70 S6 Kinase beta Thr228, p-P70 S6 Kinase beta T228, 70 kDa ribosomal protein S6 kinase 2, p70 beta, p70 ribosomal S6 kinase beta, p70 S6 kinase beta, p70 S6KB, p70 S6Kbeta, p70S6K beta, p70-beta, p70-S6KB, p70S6Kb, Ribosomal protein S6 kinase 70 kDa, polypeptide 2, Ribosomal protein S6 kinase beta 2, Ribosomal protein S6 kinase beta-2, RPS6KB2, S6 kinase related kinase, S6 kinase-related kinase, S6K beta 2, S6K beta, S6K-beta, S6K2, Serine/threonine protein kinase 14 beta, Serine/threonine-protein kinase 14 beta, SRK, STK14B.

Background: This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013].

Molecular Weight: 70kDa

Pathways: PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway