ANTXR1 antibody (AA 33-301) (Fluoro647)

Catalog No. ABIN7969123

The Rabbit Polyclonal anti-ANTXR1 antibody is suitable to detect ANTXR1 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for ANTXR1 antibody (AA 33-301) (Fluoro647) (ABIN7969123)

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANTXR1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-ANTXR1 Antibody (Fluoro647)

Binding Specificity: AA 33-301

Purpose: Anti-TEM8/ATR/ANTXR1 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TEM8/ATR/ANTXR1 recombinant protein (Position: E33-D301).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ANTXR1

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Alternative Name: ANTXR1

Background:

Background: Anthrax toxin receptor 1 (ANTXR1 or also known asTEM8) is a protein that in humans is encoded by the ANTXR1 gene. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Gene Full Name: ANTXR cell adhesion molecule 1

Gene ID: 84168

UniProt: Q9H6X2