ANTXR1 antibody (AA 33-301)

Catalog No. ABIN7969124

The Rabbit Polyclonal anti-ANTXR1 antibody (ABIN7969124) specifically detects ANTXR1 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ANTXR1 antibody (AA 33-301) (ABIN7969124)

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANTXR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Product Details anti-ANTXR1 Antibody

Binding Specificity: AA 33-301

Purpose: Anti-TEM8/ATR/ANTXR1 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-TEM8/ATR/ANTXR1 Antibody. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TEM8/ATR/ANTXR1 recombinant protein (Position: E33-D301).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse, Rat ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ANTXR1

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Alternative Name: ANTXR1

Background:

Background: Anthrax toxin receptor 1 (ANTXR1 or also known asTEM8) is a protein that in humans is encoded by the ANTXR1 gene. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Gene Full Name: ANTXR cell adhesion molecule 1

Molecular Weight: 80 kDa

Gene ID: 84168

UniProt: Q9H6X2