APC2 antibody (N-Term) (HRP)

Catalog No. ABIN7969230

This Rabbit Polyclonal antibody specifically detects APC2 in ELISA, WB and IHC. It exhibits reactivity toward Human.

Quick Overview for APC2 antibody (N-Term) (HRP) (ABIN7969230)

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC2 antibody is conjugated to HRP

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-APC2 Antibody (HRP)

Binding Specificity: N-Term

Purpose: Anti-APC2 Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: different from the related mouse sequence by two amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human APC2, different from the related mouse sequence by two amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for APC2

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Alternative Name: APC2

Background:

Background: APC2, which is also called APCL, is a deduced 2,303-amino acid protein that contains an N-terminal coiled-coil domain, followed by an armadillo domain and five 20-amino acid repeats. The human APC2 gene is mapped to chromosome 19p13.3. It is found that the 20-amino acid repeat domain of APCL could bind beta-catenin (CTNNB1) and deplete the intracellular beta-catenin pool. A reporter gene assay revealed that APCL could regulate interaction of beta-catenin with T cell-specific transcription factors (TCF7), although less efficiently than APC.

Gene Full Name: APC regulator of Wnt signaling pathway 2

Gene ID: 10297

UniProt: O95996

Pathways: WNT Signaling