Aryl Hydrocarbon Receptor antibody (C-Term) (Fluoro647)

Catalog No. ABIN7970234

The Fluoro647-conjugated Rabbit Polyclonal anti-Aryl Hydrocarbon Receptor antibody (ABIN7970234) specifically detects Aryl Hydrocarbon Receptor in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Aryl Hydrocarbon Receptor antibody (C-Term) (Fluoro647) (ABIN7970234)

Target: Aryl Hydrocarbon Receptor (AHR)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aryl Hydrocarbon Receptor antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-Aryl Hydrocarbon Receptor Antibody (Fluoro647)

Binding Specificity: C-Term

Purpose: Anti-Aryl hydrocarbon Receptor/AHR Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human AHR.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Aryl Hydrocarbon Receptor

Target: Aryl Hydrocarbon Receptor (AHR)

Alternative Name: AHR

Background:

Background: AHR (aryl hydrocarbon receptor), also called bHLHe76, is a member of the family of basic helix-loop-helix transcription factors. AhR is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. The AHR gene is mapped on 7p21.1. Estrogenic actions of AHR agonists were detected in wildtype ovariectomized mouse uteri, but were absent in Ahr -/- or Er-alpha -/- ovariectomized mice. Complex assembly and ubiquitin ligase activity of CUL4B (AHR) in vitro and in vivo are dependent on the AHR ligand. In the CUL4B (AHR) complex, ligand-activated AHR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation. Cd4-positive cells from mice lacking Ahr developed Th17 responses but failed to produce Il22 and did not show enhanced Th17 development. Activation of Ahr during induction of EAE accelerated disease onset and increased pathology in wildtype mice, but not in Ahr -/- mice. The TDO-AHR pathway is active in human brain tumors and is associated with malignant progression and poor survival. Ahr activity within ROR-gamma-t-positive ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae.

Gene Full Name: aryl hydrocarbon receptor

Sequence Similarities: Contains 1 bHLH (basic helix-loop-helix) domain.

Gene ID: 196

UniProt: P35869

Pathways: Regulation of Cell Size