ATR antibody (AA 24-1324)

Catalog No. ABIN7971503

The Rabbit Polyclonal anti-ATR antibody (ABIN7971503) specifically detects ATR in ELISA, IF and ICC. The antibody is reactive with Human samples.

Quick Overview for ATR antibody (AA 24-1324) (ABIN7971503)

Target: ATR (ATR serine/threonine kinase (ATR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATR antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Grade: Carrier-free

Product Details anti-ATR Antibody

Binding Specificity: AA 24-1324

Purpose: Anti-ATR Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-ATR Antibody. Tested in ELISA, IF, ICC applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human ATR recombinant protein (Position: E24-D1324).

Isotype: IgG

Application Details

Application Notes: Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ATR

Target: ATR (ATR serine/threonine kinase (ATR))

Alternative Name: ATR

Background:

Background: Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.

Gene Full Name: ATR checkpoint kinase

Molecular Weight: 301 kDa

Gene ID: 545

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus