Axin antibody (AA 1-811) (Fluoro647)

Catalog No. ABIN7971712

The Rabbit Polyclonal anti-Axin antibody is suitable to detect Axin in samples from Human. It has been validated for FACS.

Quick Overview for Axin antibody (AA 1-811) (Fluoro647) (ABIN7971712)

Target: Axin (AXIN1) (Axin 1 (AXIN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Axin antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-Axin Antibody (Fluoro647)

Binding Specificity: AA 1-811

Purpose: Anti-AXIN1 Antibody Fluoro647 Conjugated

Predicted Reactivity: Human AXIN1 shares 86.2%,82.8% amino acid (aa) sequence identity with mouse,rat AXIN1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human AXIN1 recombinant protein (Position: M1-K811). Human AXIN1 shares 86.2% and 82.8% amino acid (aa) sequence identity with mouse and rat AXIN1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Axin

Target: Axin (AXIN1) (Axin 1 (AXIN1))

Alternative Name: AXIN1

Background:

Background: Axin-1 is a protein that in humans is encoded by the AXIN1 gene. This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.

Gene Full Name: axin 1

Gene ID: 8312

UniProt: O15169

Pathways: WNT Signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling