Survivin antibody (AA 1-140) (FITC)

Catalog No. ABIN7972016

The FITC-conjugated Rabbit Polyclonal anti-Survivin antibody (ABIN7972016) specifically detects Survivin in FACS. The antibody is reactive with Mouse samples.

Quick Overview for Survivin antibody (AA 1-140) (FITC) (ABIN7972016)

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Survivin antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-Survivin Antibody (FITC)

Binding Specificity: AA 1-140

Purpose: Anti-Survivin/BIRC5 Antibody FITC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Mouse Survivin shares 85%,91% amino acid (aa) sequence identity with human,rat Survivin,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Survivin recombinant protein (Position: M1-A140). Mouse Survivin shares 85% and 91% amino acid (aa) sequence identity with human and rat Survivin, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Survivin

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Alternative Name: BIRC5

Background:

Background: Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that in humans encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin gene contains 4 exons. This gene is mapped to chromosome 17q25 by pulsed field gel electrophoresis and single- and 2-color FISH. The survivin protein functions as inhibitor caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.

Gene Full Name: baculoviral IAP repeat-containing 5

Sequence Similarities: Belongs to the IAP family.

Gene ID: 11799

UniProt: O70201

Pathways: Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding