BIM antibody (AA 18-186) (Fluoro647)

Catalog No. ABIN7972473

This Rabbit Polyclonal antibody specifically detects BIM in FACS. It exhibits reactivity toward Mouse.

Quick Overview for BIM antibody (AA 18-186) (Fluoro647) (ABIN7972473)

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIM antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-BIM Antibody (Fluoro647)

Binding Specificity: AA 18-186

Purpose: Anti-Bim/Bcl2l11 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Mouse Bcl2l11 shares 86.7%,98.8% amino acid (aa) sequence identity with human,rat Bcl2l11,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Bim/Bcl2l11 recombinant protein (Position: Q18-R186). Mouse Bcl2l11 shares 86.7% and 98.8% amino acid (aa) sequence identity with human and rat Bcl2l11, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for BIM

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Alternative Name: Bcl2l11

Background:

Background: Bcl-2-like protein 11, commonly called BIM (Bcl-2?Interacting?Mediator of cell death), is a?protein?that in humans is encoded by the?BCL2L11?gene. BCL2 is a prototypic mammalian regulator of cell death. Certain members of the BCL2 family inhibit apoptosis, while other members facilitate this physiologic process of cell death. By screening a cDNA expression library using recombinant BCL2 as bait, O'Connor et al. isolated a small novel protein, which they referred to as BIM, with a 9-amino acid BH3 motif shared by most BCL2 homologs. BIM provokes apoptosis, and the BH3 region is required for BCL2 binding and for most of its cytotoxicity.

Gene Full Name: BCL2 like 11

Gene ID: 12125

UniProt: O54918

Pathways: PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity