Bestrophin 1 antibody (AA 9-551) (Fluoro647)

Catalog No. ABIN7972606

The Rabbit Polyclonal anti-Bestrophin 1 antibody is suitable to detect Bestrophin 1 in samples from Mouse and Rat. It has been validated for FACS.

Quick Overview for Bestrophin 1 antibody (AA 9-551) (Fluoro647) (ABIN7972606)

Target: Bestrophin 1 (BEST1)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Bestrophin 1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-Bestrophin 1 Antibody (Fluoro647)

Binding Specificity: AA 9-551

Purpose: Anti-Bestrophin-1/Best1 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Mouse Best1 shares 64.3% amino acid (aa) sequence identity with human Best1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Bestrophin-1/Best1 recombinant protein (Position: V9-E551). Mouse Best1 shares 64.3% amino acid (aa) sequence identity with human Best1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Bestrophin 1

Target: Bestrophin 1 (BEST1)

Alternative Name: Best1

Background:

Background: Bestrophin-1 (Best1) is a protein that, in humans, is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

Gene Full Name: bestrophin 1

Gene ID: 24115

UniProt: O88870