BMPR1A antibody (Middle Region) (APC)

Catalog No. ABIN7972912

The Rabbit Polyclonal anti-BMPR1A antibody is suitable to detect BMPR1A in samples from Human and Rat. It has been validated for FACS.

Quick Overview for BMPR1A antibody (Middle Region) (APC) (ABIN7972912)

Target: BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMPR1A antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-BMPR1A Antibody (APC)

Binding Specificity: Middle Region

Purpose: Anti-BMPR1A Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human BMPR1A, which shares 95.8% amino acid (aa) sequence identity with mouse BMPR1A.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for BMPR1A

Target: BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

Alternative Name: BMPR1A

Background:

Background: The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Gene Full Name: bone morphogenetic protein receptor type 1A

Gene ID: 657

UniProt: P36894

Pathways: Stem Cell Maintenance