CAMLG antibody (Middle Region) (HRP)

Catalog No. ABIN7974122

The HRP-conjugated Rabbit Polyclonal anti-CAMLG antibody (ABIN7974122) specifically detects CAMLG in WB, IHC and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for CAMLG antibody (Middle Region) (HRP) (ABIN7974122)

Target: CAMLG (Calcium Modulating Ligand (CAMLG))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAMLG antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-CAMLG Antibody (HRP)

Binding Specificity: Middle Region

Purpose: Anti-CAMLG Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human CAMLG shares 91.7%,95.7% amino acid (aa) sequence identity with mouse,rat CAMLG,respectively.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human CAMLG. Human CAMLG shares 91.7% and 95.7% amino acid (aa) sequence identity with mouse and rat CAMLG, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CAMLG

Target: CAMLG (Calcium Modulating Ligand (CAMLG))

Alternative Name: CAMLG

Background:

Background: The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

Gene Full Name: calcium modulating ligand

Gene ID: 819

UniProt: P49069

Pathways: EGFR Signaling Pathway