CAMLG antibody (Middle Region) (PE)

Catalog No. ABIN7974124

The Rabbit Polyclonal anti-CAMLG antibody is suitable to detect CAMLG in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for CAMLG antibody (Middle Region) (PE) (ABIN7974124)

Target: CAMLG (Calcium Modulating Ligand (CAMLG))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAMLG antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-CAMLG Antibody (PE)

Binding Specificity: Middle Region

Purpose: Anti-CAMLG Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human CAMLG shares 91.7%,95.7% amino acid (aa) sequence identity with mouse,rat CAMLG,respectively.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human CAMLG. Human CAMLG shares 91.7% and 95.7% amino acid (aa) sequence identity with mouse and rat CAMLG, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CAMLG

Target: CAMLG (Calcium Modulating Ligand (CAMLG))

Alternative Name: CAMLG

Background:

Background: The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

Gene Full Name: calcium modulating ligand

Gene ID: 819

UniProt: P49069

Pathways: EGFR Signaling Pathway