CPB2 antibody (AA 166-388)

Catalog No. ABIN7974852

This Rabbit Polyclonal antibody specifically detects CPB2 in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for CPB2 antibody (AA 166-388) (ABIN7974852)

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Grade: Carrier-free

Product Details anti-CPB2 Antibody

Binding Specificity: AA 166-388

Purpose: Anti-Carboxypeptidase B2/CPB2 Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: coli-derived human CPB2 recombinant protein (Position: K166-D388). Human CPB2 shares 86.1%,85.7% amino acid (aa) sequence identity with mouse,rat CPB2,respectively.

Characteristics: Anti-Carboxypeptidase B2/CPB2 Antibody. Tested in ELISA, IHC, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human CPB2 recombinant protein (Position: K166-D388). Human CPB2 shares 86.1% and 85.7% amino acid (aa) sequence identity with mouse and rat CPB2, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human ELISA(Cap) , 1-5 μg/mL, Human, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CPB2

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Alternative Name: CPB2

Background:

Background: Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

Gene Full Name: carboxypeptidase B2

Molecular Weight: 48 kDa, 60 kDa

Gene ID: 1361

UniProt: Q96IY4

Pathways: Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis