CPB2 antibody (AA 165-387) (HRP)

Catalog No. ABIN7974859

The Rabbit Polyclonal anti-CPB2 antibody is suitable to detect CPB2 in samples from Mouse. It has been validated for WB, IHC and ELISA.

Quick Overview for CPB2 antibody (AA 165-387) (HRP) (ABIN7974859)

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPB2 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-CPB2 Antibody (HRP)

Binding Specificity: AA 165-387

Purpose: Anti-Carboxypeptidase B2/CPB2 Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: coli-derived mouse CPB2 recombinant protein (Position: K165-D387). Mouse CPB2 shares 86.1%,96.9% amino acid (aa) sequence identity with human,rat CPB2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived mouse CPB2 recombinant protein (Position: K165-D387). Mouse CPB2 shares 86.1% and 96.9% amino acid (aa) sequence identity with human and rat CPB2, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CPB2

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Alternative Name: Cpb2

Background:

Background: Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

Gene Full Name: carboxypeptidase B2

Gene ID: 56373

UniProt: Q9JHH6

Pathways: Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis