CSNK1A1 antibody (N-Term) (Cy3)

Catalog No. ABIN7975086

This Rabbit Polyclonal antibody specifically detects CSNK1A1 in FACS. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for CSNK1A1 antibody (N-Term) (Cy3) (ABIN7975086)

Target: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSNK1A1 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-CSNK1A1 Antibody (Cy3)

Binding Specificity: N-Term

Purpose: Anti-Caseine Kinase 1 alpha/CSNK1A1 Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related mouse,rat sequences.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human CSNK1A1, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CSNK1A1

Target: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Alternative Name: CSNK1A1

Background:

Background: Casein kinase I isoform alpha?is an?enzyme?that in humans is encoded by the?CSNK1A1?gene. The?CSNK1A1?gene is mapped to chromosome 5q32 based on an alignment of the?CSNK1A1?sequence with the genomic sequence (GRCh37). It is reported that both screens identified CK1-alpha as a bifunctional regulator of NF-kappa-B. CK1-alpha dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation. However, CK1-alpha kinase activity has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1. CK1-alpha has thus a dual 'gating' function which first promotes and then terminates receptor-induced NF-kappa-B. ABC DLBCL cells required CK1-alpha for constitutive NF-kappa-B activity, indicating that CK1-alpha functions as a conditionally essential malignancy gene.?

Gene Full Name: casein kinase 1 alpha 1

Gene ID: 1452

UniProt: P48729

Pathways: WNT Signaling, Hedgehog Signaling