Cathepsin D antibody (AA 65-412) (Fluoro594)

Catalog No. ABIN7975859

The Fluoro594-conjugated Rabbit Polyclonal anti-Cathepsin D antibody (ABIN7975859) specifically detects Cathepsin D in FACS. The antibody is reactive with Human samples.

Quick Overview for Cathepsin D antibody (AA 65-412) (Fluoro594) (ABIN7975859)

Target: Cathepsin D (CTSD)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin D antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-Cathepsin D Antibody (Fluoro594)

Binding Specificity: AA 65-412

Purpose: Anti-Cathepsin D/CTSD Antibody Fluoro594 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human Cathepsin D shares 85% amino acid (aa) sequence identity with both mouse,rat Cathepsin D.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Cathepsin D recombinant protein (Position: G65-L412). Human Cathepsin D shares 85% amino acid (aa) sequence identity with both mouse and rat Cathepsin D.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Cathepsin D

Target: Cathepsin D (CTSD)

Alternative Name: CTSD

Background:

Background: Cathepsin D is a protein that in humans is encoded by the CTSD gene. This proteinase is a member of the peptidase C1 family, having a specificity similar to but narrower than that of pepsin A. It is mapped to 11p15.5. The cDNA encodes a 412-amino acid protein with 20 and 44 amino acids in a pre- and prosegment, respectively. Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease and it has been considered as a breast cancer tumor marker.

Gene Full Name: cathepsin D

Sequence Similarities: Belongs to the peptidase A1 family.

Gene ID: 1509

UniProt: P07339

Pathways: Peptide Hormone Metabolism