CD59 antibody (AA 26-102) (FITC)

Catalog No. ABIN7977169

The Rabbit Polyclonal anti-CD59 antibody is suitable to detect CD59 in samples from Human. It has been validated for FACS.

Quick Overview for CD59 antibody (AA 26-102) (FITC) (ABIN7977169)

Target: CD59

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD59 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-CD59 Antibody (FITC)

Binding Specificity: AA 26-102

Purpose: Anti-CD59 glycoprotein CD59 Antibody FITC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human CD59 shares 47.1% amino acid (aa) sequence identity with rat CD59.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CD59 recombinant protein (Position: L26-N102). Human CD59 shares 47.1% amino acid (aa) sequence identity with rat CD59.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CD59

Target: CD59

Alternative Name: CD59

Background:

Background: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. And this protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Gene Full Name: CD59 Molecule (CD59 blood group)

Sequence Similarities: Contains 1 UPAR/Ly6 domain.

Gene ID: 966

UniProt: P13987

Pathways: Complement System