CENPE antibody (AA 1390-2474) (APC)

Catalog No. ABIN7978063

The Rabbit Polyclonal anti-CENPE antibody is suitable to detect CENPE in samples from Rat and Mouse. It has been validated for FACS.

Quick Overview for CENPE antibody (AA 1390-2474) (APC) (ABIN7978063)

Target: CENPE (Centromere Protein E, 312kDa (CENPE))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CENPE antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-CENPE Antibody (APC)

Binding Specificity: AA 1390-2474

Purpose: Anti-Cenpe Antibody APC Conjugated

Predicted Reactivity: Mouse Cenpe shares 49.9% amino acid (aa) sequence identity with human Cenpe,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Cenpe recombinant protein (Position: Q1390-Q2474). Mouse Cenpe shares 49.9% amino acid (aa) sequence identity with human Cenpe, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CENPE

Target: CENPE (Centromere Protein E, 312kDa (CENPE))

Alternative Name: Cenpe

Background:

Background: Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene. Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.

Gene Full Name: centromere protein E

Gene ID: 229841

UniProt: Q6RT24

Pathways: M Phase, Maintenance of Protein Location