CXCR1 antibody (N-Term) (Fluoro550)

Catalog No. ABIN7979248

The Rabbit Polyclonal anti-CXCR1 antibody is suitable to detect CXCR1 in samples from Human. It has been validated for FACS.

Quick Overview for CXCR1 antibody (N-Term) (Fluoro550) (ABIN7979248)

Target: CXCR1 (Chemokine (C-X-C Motif) Receptor 1 (CXCR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR1 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-CXCR1 Antibody (Fluoro550)

Binding Specificity: N-Term

Purpose: Anti-CXCR1 Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CXCR1

Target: CXCR1 (Chemokine (C-X-C Motif) Receptor 1 (CXCR1))

Alternative Name: CXCR1

Background:

Background: CXCR1 (Chemokine,CXC Motif, Receptor 1), also known as IL8RA or IL8R1, is a chemokine receptor. IL8RA is its human gene. Morris et al. (1992) mapped the IL8RA gene to chromosome 2q35. Hartl et al. (2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases. Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Gene Full Name: C-X-C motif chemokine receptor 1

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

Gene ID: 3577

UniProt: P25024

Pathways: cAMP Metabolic Process