CNTF antibody (AA 12-200) (Biotin)

Catalog No. ABIN7980225

This Rabbit Polyclonal antibody specifically detects CNTF in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for CNTF antibody (AA 12-200) (Biotin) (ABIN7980225)

Target: CNTF (Ciliary Neurotrophic Factor (CNTF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNTF antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-CNTF Antibody (Biotin)

Binding Specificity: AA 12-200

Purpose: Anti-CNTF Antibody Biotin Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: coli-derived human CNTF recombinant protein (Position: H12-M200). Human CNTF shares 84.1%,85.2% amino acid (aa) sequence identity with mouse,rat CNTF,respectively.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human CNTF recombinant protein (Position: H12-M200). Human CNTF shares 84.1% and 85.2% amino acid (aa) sequence identity with mouse and rat CNTF, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CNTF

Target: CNTF (Ciliary Neurotrophic Factor (CNTF))

Alternative Name: CNTF

Background:

Background: Ciliary neurotrophic factor (CNTF) is a potent polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes survival, neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. This gene is located on chromosome 11, as determined using human-hamster somatic cell hybrids. The CNTF protein is highly conserved in evolution. The amino acid (aa) sequences of rat and rabbit CNTF translated from cDNAs display approx. 85 % homology with the deduced aa sequence encoding human CNTF. CNTF induces weight loss and improves glucose tolerance in humans and rodents. It is thought to act centrally by inducing hypothalamic neurogenesis to modulate food intake and peripherally by altering hepatic gene expression, in a manner similar to that of leptin.

Gene Full Name: ciliary neurotrophic factor

Gene ID: 1270

UniProt: P26441

Pathways: JAK-STAT Signaling