Claudin 18 antibody (AA 31-261) (Fluoro594)

Catalog No. ABIN7980405

This Rabbit Polyclonal antibody specifically detects Claudin 18 in FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for Claudin 18 antibody (AA 31-261) (Fluoro594) (ABIN7980405)

Target: Claudin 18 (CLDN18)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 18 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-Claudin 18 Antibody (Fluoro594)

Binding Specificity: AA 31-261

Purpose: Anti-Claudin18/CLDN18 Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Claudin18/CLDN18 recombinant protein (Position: S31-V261).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Claudin 18

Target: Claudin 18 (CLDN18)

Alternative Name: CLDN18

Background:

Background: Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Full Name: claudin 18

Gene ID: 51208

UniProt: P56856

Pathways: Cell-Cell Junction Organization, Hepatitis C