Claudin 2 antibody (AA 38-230)

Catalog No. ABIN7980422

The Rabbit Polyclonal anti-Claudin 2 antibody (ABIN7980422) specifically detects Claudin 2 in WB and IHC. The antibody is reactive with Human and Rat samples.

Quick Overview for Claudin 2 antibody (AA 38-230) (ABIN7980422)

Target: Claudin 2 (CLDN2)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Product Details anti-Claudin 2 Antibody

Binding Specificity: AA 38-230

Purpose: Anti-Claudin 2/CLDN2 Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human Claudin 2 shares 92% amino acid (aa) sequence identity with mouse Claudin 2.

Characteristics: Anti-Claudin 2/CLDN2 Antibody. Tested in IHC, WB applications. This antibody reacts with Human, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Claudin 2 recombinant protein (Position: A38-V230). Human Claudin 2 shares 92% amino acid (aa) sequence identity with mouse Claudin 2.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, HumanWestern blot, 0.1-0.5 μg/mL, Rat, Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Claudin 2

Target: Claudin 2 (CLDN2)

Alternative Name: CLDN2

Background:

Background: Claudin-2 is a protein that in humans is encoded by the CLDN2 gene. By genomic sequence analysis, this gene is mapped to chromosome Xq22.3-q23. This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. By expression in a human intestinal epithelial cell line, it was determined that the intestine-specific homeodomain proteins CDX1 and CDX2 activated a reporter plasmid driven by the CLDN2 promoter.

Gene Full Name: claudin 2

Molecular Weight: 25 kDa

Gene ID: 9075

UniProt: P57739

Pathways: Hepatitis C