Prothrombin antibody (C-Term) (Fluoro488)

Catalog No. ABIN7980700

The Rabbit Polyclonal anti-Prothrombin antibody is suitable to detect Prothrombin in samples from Rat. It has been validated for FACS.

Quick Overview for Prothrombin antibody (C-Term) (Fluoro488) (ABIN7980700)

Target: Prothrombin (F2) (Coagulation Factor II (thrombin) (F2))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prothrombin antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-Prothrombin Antibody (Fluoro488)

Binding Specificity: C-Term

Purpose: Anti-Prothrombin/F2 Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of rat Prothrombin.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Prothrombin

Target: Prothrombin (F2) (Coagulation Factor II (thrombin) (F2))

Alternative Name: F2

Background:

Background: F2 (Coagulation Factor II), also known as thrombin, is a serine protease that in humans is encoded by the F2 gene. Royle et al. (1987) assigned the gene for human prothrombin (F2) to chromosome 11p11-q12 by analysis of a panel of somatic cell hybrid DNAs and by in situ hybridization, using both cDNA and genomic probes. The activated thrombin enzyme plays an important role in hemostasis and thrombosis: it converts fibrinogen to fibrin for blood clot formation, stimulates platelet aggregation, and activates coagulation factors V, VIII (F8), and XIII (F13A1). Thrombin also inhibits coagulation by activating protein C.

Gene Full Name: coagulation factor II(thrombin)

Sequence Similarities: Belongs to the peptidase S1 family.

Gene ID: 29251

UniProt: P18292

Pathways: Complement System, Peptide Hormone Metabolism, Regulation of G-Protein Coupled Receptor Protein Signaling