M-CSF/CSF1 antibody (AA 33-262) (Fluoro647)

Catalog No. ABIN7981259

The Fluoro647-conjugated Rabbit Polyclonal anti-M-CSF/CSF1 antibody (ABIN7981259) specifically detects M-CSF/CSF1 in FACS. The antibody is reactive with Mouse and Rat samples.

Quick Overview for M-CSF/CSF1 antibody (AA 33-262) (Fluoro647) (ABIN7981259)

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This M-CSF/CSF1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-M-CSF/CSF1 Antibody (Fluoro647)

Binding Specificity: AA 33-262

Purpose: Anti-MCSF/CSF1 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: coli-derived mouse MCSF recombinant protein (Position: K33-E262). Mouse MCSF shares 80.9 %,88.6% amino acid (aa) sequence identity with human,rat MCSF,respectively.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived mouse MCSF recombinant protein (Position: K33-E262). Mouse MCSF shares 80.9 % and 88.6% amino acid (aa) sequence identity with human and rat MCSF, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for M-CSF/CSF1

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Alternative Name: Csf1

Background:

Background: M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival ofmonocytes, macrophages, and bone marrow progenitor cells. M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy.

Gene Full Name: colony stimulating factor 1 (macrophage)

Sequence Similarities: Contains 5 cadherin domains.

Gene ID: 12977

UniProt: P07141

Pathways: RTK Signaling