C5 antibody (AA 1-77) (HRP)

Catalog No. ABIN7981388

The HRP-conjugated Rabbit Polyclonal anti-C5 antibody (ABIN7981388) specifically detects C5 in WB, ELISA and IHC. The antibody is reactive with Rat samples.

Quick Overview for C5 antibody (AA 1-77) (HRP) (ABIN7981388)

Target: C5 (Complement Component 5 (C5))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C5 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-C5 Antibody (HRP)

Binding Specificity: AA 1-77

Purpose: Anti-C5/C5a Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Rat C5a shares 62%,82% amino acid (aa) sequences identity with human,mouse C5a,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived rat C5a recombinant protein (Position: D1-R77). Rat C5a shares 62% and 82% amino acid (aa) sequences identity with human and mouse C5a, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for C5

Target: C5 (Complement Component 5 (C5))

Alternative Name: C5

Background:

Background: C5a is a protein fragment released from complement component C5. This gene is mapped to 9q33.2. The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. C5a plays a key role in increasing migration and adherence of neutrophils and monocytes to vessel walls. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to susceptibility to liver fibrosis and to rheumatoid arthritis.

Gene Full Name: complement component 5

Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family.

Gene ID: 362119

UniProt: P08650

Pathways: Complement System, Carbohydrate Homeostasis