Coxsackie Adenovirus Receptor antibody (AA 35-365) (Fluoro647)

Catalog No. ABIN7981743

This Rabbit Polyclonal antibody specifically detects Coxsackie Adenovirus Receptor in FACS. It exhibits reactivity toward Human, Mouse, Rat and Monkey.

Quick Overview for Coxsackie Adenovirus Receptor antibody (AA 35-365) (Fluoro647) (ABIN7981743)

Target: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Coxsackie Adenovirus Receptor antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-Coxsackie Adenovirus Receptor Antibody (Fluoro647)

Binding Specificity: AA 35-365

Purpose: Anti-CXADR Antibody Fluoro647 Conjugated

Predicted Reactivity: Human CXADR shares 91.2%,91.5% amino acid (aa) sequence identity with mouse,rat CXADR,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CXADR recombinant protein (Position: E35-V365). Human CXADR shares 91.2% and 91.5% amino acid (aa) sequence identity with mouse and rat CXADR, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Coxsackie Adenovirus Receptor

Target: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Alternative Name: CXADR

Background:

Background: CXADR(Coxsackie virus and adenovirus receptor) is a protein that in humans is encoded by the CXADR gene, also known as CAR,CVB3-binding protein, Coxsackievirus B-adenovirus receptor. The CAR cDNA encodes a predicted 365-amino acid polypeptide that contains a single transmembrane domain and is a member of the immunoglobulin superfamily. By Northern blot analysis, they detected highest expression of 1.4-kb and 6-kb CXADR transcripts in pancreas, brain, heart, small intestine, testis, and prostate, lower expression in liver and lung, and no expression in kidney, placenta, peripheral blood leukocytes, thymus, and spleen. In comparison, mouse Cxadr showed highest expression in liver, and lower levels in kidney, heart, lung, and brain. The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins , such as: fibronectin, agrin, laminin-1 and tenascin-R.

Gene Full Name: CXADR cell adhesion molecule

Gene ID: 1525

UniProt: P78310

Pathways: Cell-Cell Junction Organization