Cullin 1 antibody (N-Term) (Fluoro647)

Catalog No. ABIN7981997

The Fluoro647-conjugated Rabbit Polyclonal anti-Cullin 1 antibody (ABIN7981997) specifically detects Cullin 1 in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Cullin 1 antibody (N-Term) (Fluoro647) (ABIN7981997)

Target: Cullin 1 (CUL1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cullin 1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-Cullin 1 Antibody (Fluoro647)

Binding Specificity: N-Term

Purpose: Anti-Cullin 1/Cul1 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related mouse,rat sequences.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Cullin 1, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Cullin 1

Target: Cullin 1 (CUL1)

Alternative Name: Cul1

Background:

Background: Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination. This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Human cullin 1, but not the other closely related cullins 2, 3, 4A, and 5, selectively interacts with human SKP1.

Gene Full Name: cullin 1

Sequence Similarities: Contains 1 bHLH (basic helix-loop-helix) domain.

UniProt: Q13616

Pathways: Cell Division Cycle, Hedgehog Signaling, Mitotic G1-G1/S Phases, Regulation of Cell Size