Cyclin A1 antibody (AA 64-263) (Cy3)

Catalog No. ABIN7982100

This Rabbit Polyclonal antibody specifically detects Cyclin A1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Cyclin A1 antibody (AA 64-263) (Cy3) (ABIN7982100)

Target: Cyclin A1 (CCNA1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin A1 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-Cyclin A1 Antibody (Cy3)

Binding Specificity: AA 64-263

Purpose: Anti-Cyclin A1/CCNA1 Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human Cyclin A1 shares 78.5%,79.5% amino acid (aa) sequence identity with mouse,rat Cyclin A1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Cyclin A1 recombinant protein (Position: D64-E263). Human Cyclin A1 shares 78.5% and 79.5% amino acid (aa) sequence identity with mouse and rat Cyclin A1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Cyclin A1

Target: Cyclin A1 (CCNA1)

Alternative Name: CCNA1

Background:

Background: Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. Also this cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: cyclin A1

Sequence Similarities: Belongs to the cyclin family. Cyclin AB subfamily.

Gene ID: 8900

UniProt: P78396

Pathways: Apoptosis, Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA