CYLD antibody (AA 618-956) (HRP)

Catalog No. ABIN7982578

The Rabbit Polyclonal anti-CYLD antibody is suitable to detect CYLD in samples from Human and Rat. It has been validated for WB, ELISA and IHC.

Quick Overview for CYLD antibody (AA 618-956) (HRP) (ABIN7982578)

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYLD antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-CYLD Antibody (HRP)

Binding Specificity: AA 618-956

Purpose: Anti-CYLD Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human CYLD shares 97.6%,97.9% amino acid (aa) sequence identity with mouse,rat CYLD,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CYLD recombinant protein (Position: D618-K956). Human CYLD shares 97.6% and 97.9% amino acid (aa) sequence identity with mouse and rat CYLD, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CYLD

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Alternative Name: CYLD

Background:

Background: CYLD is localized on the long arm of chromosome 16. This gene encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene Full Name: CYLD lysine 63 deubiquitinase

Sequence Similarities: Belongs to the peptidase C19 family.

Gene ID: 1540

UniProt: Q9NQC7

Pathways: Apoptosis, Activation of Innate immune Response