DDB2 antibody (AA 10-424)

Catalog No. ABIN7983774

This Rabbit Polyclonal antibody specifically detects DDB2 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for DDB2 antibody (AA 10-424) (ABIN7983774)

Target: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-DDB2 Antibody

Binding Specificity: AA 10-424

Purpose: Anti-DDB2 Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-DDB2 Antibody. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human DDB2 recombinant protein (Position: Q10-R424).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Flow Cytometry(Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DDB2

Target: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Alternative Name: DDB2

Background:

Background: DNA damage-binding protein 2?is a?protein?that in humans is encoded by the?DDB2?gene. This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. And this subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: damage specific DNA binding protein 2

Molecular Weight: 48 kDa

Gene ID: 1643

UniProt: Q92466

Pathways: DNA Damage Repair