DOCK1 antibody (AA 100-1732) (Biotin)

Catalog No. ABIN7984570

The Rabbit Polyclonal anti-DOCK1 antibody is suitable to detect DOCK1 in samples from Human. It has been validated for WB, ELISA and IHC.

Quick Overview for DOCK1 antibody (AA 100-1732) (Biotin) (ABIN7984570)

Target: DOCK1 (Dedicator of Cytokinesis 1 (DOCK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-DOCK1 Antibody (Biotin)

Binding Specificity: AA 100-1732

Purpose: Anti-DOCK180/DOCK1 Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human DOCK180/DOCK1 recombinant protein (Position: S100-T1732).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for DOCK1

Target: DOCK1 (Dedicator of Cytokinesis 1 (DOCK1))

Alternative Name: DOCK1

Background:

Background: Dock180, (Dedicator of cytokinesis) also known as DOCK1, is a large (~180 kDa) protein involved in intracellular signalling networks. This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants.

Gene Full Name: dedicator of cytokinesis 1

Gene ID: 1793

UniProt: Q14185

Pathways: Signaling of Hepatocyte Growth Factor Receptor