DOCK3 antibody (AA 88-2006) (Fluoro647)

Catalog No. ABIN7984602

This Rabbit Polyclonal antibody specifically detects DOCK3 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for DOCK3 antibody (AA 88-2006) (Fluoro647) (ABIN7984602)

Target: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK3 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-DOCK3 Antibody (Fluoro647)

Binding Specificity: AA 88-2006

Purpose: Anti-MOCA/DOCK3 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human MOCA,DOCK3 shares 98% amino acid (aa) sequence identity with mouse MOCA,DOCK3.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MOCA/DOCK3 recombinant protein (Position: E88-K2006). Human MOCA/DOCK3 shares 98% amino acid (aa) sequence identity with mouse MOCA/DOCK3.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for DOCK3

Target: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Alternative Name: DOCK3

Background:

Background: This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement.

Gene Full Name: dedicator of cytokinesis 3

Gene ID: 1795

UniProt: Q8IZD9