DLL3 antibody (C-Term) (Fluoro550)

Catalog No. ABIN7984778

The Fluoro550-conjugated Rabbit Polyclonal anti-DLL3 antibody (ABIN7984778) specifically detects DLL3 in FACS. The antibody is reactive with Human samples.

Quick Overview for DLL3 antibody (C-Term) (Fluoro550) (ABIN7984778)

Target: DLL3 (delta Like Protein 3 (DLL3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLL3 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-DLL3 Antibody (Fluoro550)

Binding Specificity: C-Term

Purpose: Anti-Delta-like protein 3 DLL3 Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human DLL3.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for DLL3

Target: DLL3 (delta Like Protein 3 (DLL3))

Alternative Name: DLL3

Background:

Background: DLL3 (DELTA-LIKE 3) also known as DELTA, DROSOPHILA, HOMOLOG OF, is a protein which in humans is encoded by the DLL3 gene. This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutation in the mouse delta-like 3 gene (Dll3), which is homologous to the Notch-ligand delta in Drosophila, results in the mouse 'pudgy' phenotype. The human DLL3 gene was identified within a critical interval, mapped in 2 consanguineous Arab-Israeli and Pakistani SCDO1 pedigrees, of 7.8 cM at 19q13.1-q13.3 between D19S570 and D19S908 (Bulman et al., 2000). Dunwoodie et al. (1997) presented results suggesting that mouse Dll3 may complement the function of other delta homologs during early pattern formation in the mouse embryo. In humans, the fact that mutations in genes required for oscillation, such as DLL3, result in abnormal segmentation of the vertebral column suggests that the segmentation clock also acts during human embryonic development. This residue is highly conserved in Delta proteins from Drosophila to humans, and the substitution of a charged polar for a nonpolar residue may disrupt the conformation of the DLL3 protein.

Gene Full Name: delta like canonical Notch ligand 3

Sequence Similarities: Contains 1 DSL domain.

Gene ID: 10683

UniProt: Q9NYJ7

Pathways: Notch Signaling