Deoxyuridine Triphosphatase (DUT) (C-Term) antibody (Fluoro550)

Catalog No. ABIN7984890

This Rabbit Polyclonal antibody specifically detects Deoxyuridine Triphosphatase in FACS. It exhibits reactivity toward Human.

Quick Overview for Deoxyuridine Triphosphatase (DUT) (C-Term) antibody (Fluoro550) (ABIN7984890)

Target: Deoxyuridine Triphosphatase (DUT)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Fluoro550

Application: Flow Cytometry (FACS)

Product Details

Binding Specificity: C-Term

Purpose: Anti-DUT Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related rat,mouse sequences by two amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human DUT, different from the related rat and mouse sequences by two amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details

Target: Deoxyuridine Triphosphatase (DUT)

Alternative Name: DUT

Background:

Background: Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is responsible for maintaining low intracellular levels of dUTP, thus preventing the incorporation of dUTP into DNA. dUTPase activity/expression can be down-regulated using siRNA specifically targeted to dUTPase mRNA and dUTPase plays a role in DNA nucleotide metabolism. This protein, present predominantly in the cytoplasm, contains 252 amino acids with a Mr of 26,704. It exhibits 35 % identity with the E.coli dUTPase and 53 % identity with the Saccharomyces cerevisiae enzyme. The nuclear and mitochondrial forms of dUTPase are encoded by the same gene with isoform-specific transcripts arising through the use of alternative 5-prime exons. Human dUTPase exhibits 92 % identity with rat. Moreover, this enzyme has profound effects on the efficacy of agents that target thymidylate biosynthesis.

Gene Full Name: deoxyuridine triphosphatase

Sequence Similarities: Belongs to the dUTPase family.

Gene ID: 1854

UniProt: P33316