DISC1 antibody (N-Term) (Fluoro550)

Catalog No. ABIN7985744

The Fluoro550-conjugated Rabbit Polyclonal anti-DISC1 antibody (ABIN7985744) specifically detects DISC1 in FACS. The antibody is reactive with Human samples.

Quick Overview for DISC1 antibody (N-Term) (Fluoro550) (ABIN7985744)

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DISC1 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-DISC1 Antibody (Fluoro550)

Binding Specificity: N-Term

Purpose: Anti-DISC1 Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human DISC1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for DISC1

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Alternative Name: DISC1

Background:

Background: DISC1 (Disrupted in Schizophrenia 1), is a protein that is encoded by the DISC1 gene in humans. Ma et al. (2002) determined that the mouse Disc1 gene maps to chromosome 8 in a region with homology of synteny to human chromosome 1q42. Ozeki et al. (2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. Millar et al. (2005) showed that DISC1 interacts with the UCR2 domain of phosphodiesterase-4B, implicated in susceptibility to schizophrenia, and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity.

Gene Full Name: DISC1 scaffold protein

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

Gene ID: 27185

UniProt: Q9NRI5

Pathways: Regulation of Cell Size