DKC1 antibody (AA 19-447) (PE)

Catalog No. ABIN7986687

This Rabbit Polyclonal antibody specifically detects DKC1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for DKC1 antibody (AA 19-447) (PE) (ABIN7986687)

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKC1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-DKC1 Antibody (PE)

Binding Specificity: AA 19-447

Purpose: Anti-DKC1 Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human DKC1 shares 94.2%,87.9% amino acid (aa) sequence identity with mouse,rat DKC1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human DKC1 recombinant protein (Position: R19-R447). Human DKC1 shares 94.2% and 87.9% amino acid (aa) sequence identity with mouse and rat DKC1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for DKC1

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Alternative Name: DKC1

Background:

Background: This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.

Gene Full Name: dyskerin pseudouridine synthase 1

Gene ID: 1736

UniProt: O60832

Pathways: Telomere Maintenance