Dystrophin antibody (AA 3076-3404) (PE)

Catalog No. ABIN7986731

The PE-conjugated Rabbit Polyclonal anti-Dystrophin antibody (ABIN7986731) specifically detects Dystrophin in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Dystrophin antibody (AA 3076-3404) (PE) (ABIN7986731)

Target: Dystrophin (DMD)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dystrophin antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-Dystrophin Antibody (PE)

Binding Specificity: AA 3076-3404

Purpose: Anti-Dystrophin/DMD Antibody PE Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human Dystrophin shares 100% amino acid (aa) sequence identity with mouse Dystrophin.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Dystrophin recombinant protein (Position: H3076-D3404). Human Dystrophin shares 100% amino acid (aa) sequence identity with mouse Dystrophin.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Dystrophin

Target: Dystrophin (DMD)

Alternative Name: DMD

Background:

Background: Dystrophin, also known as DMD, is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. It is mapped to Xp21.2-p21.1. This complex is variously known as the costamere or thedystrophin-associated protein complex. Many muscle proteins, such as α-dystrobrevin, syncoilin, synemin, sarcoglycan, dystroglycan, and sarcospan, colocalize with dystrophin at the costamere. Dystrophin is a protein located between the sarcolemma and the outermost layer of myofilaments in the muscle fiber (myofiber). It is a cohesive protein, linking actin filaments to another support protein that resides on the inside surface of each muscle fiber's plasma membrane (sarcolemma).

Gene Full Name: dystrophin

Sequence Similarities: Contains 2 CH (calponin-homology) domains.

Gene ID: 1756

UniProt: P11532

Pathways: Skeletal Muscle Fiber Development