EFS antibody (AA 183-553) (Fluoro488)

Catalog No. ABIN7987423

The Rabbit Polyclonal anti-EFS antibody is suitable to detect EFS in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for EFS antibody (AA 183-553) (Fluoro488) (ABIN7987423)

Target: EFS (Embryonal Fyn-Associated Substrate (EFS))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EFS antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-EFS Antibody (Fluoro488)

Binding Specificity: AA 183-553

Purpose: Anti-EFS Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human EFS shares 82.2% amino acid (aa) sequence identity with mouse EFS.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human EFS recombinant protein (Position: E183-T553). Human EFS shares 82.2% amino acid (aa) sequence identity with mouse EFS.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for EFS

Target: EFS (Embryonal Fyn-Associated Substrate (EFS))

Alternative Name: EFS

Background:

Background: The protein encoded by this gene is a member of the CAS (CRK-associated substrate) family of adaptor proteins which typically serve as scaffolds for the assembly of larger signaling complexes. These complexes form at the cell surface where integrin binding leads to the subsequent phosphorylation of a CAS protein. Additional binding of SRC family kinases leads to CAS hyperphosphorylation and the creation of binding sites for CRK and other proteins that cause actin cytoskeleton reorganization. This gene plays a role in integrin-mediated cell attachment, spreading, and migration and also plays a role in both normal and malignant cellular transformation. This broadly expressed gene has been shown to play a role in neurite outgrowth and its expression in the thymus and lymphocytes is important for T cell maturation and the development of immunological self-tolerance. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Gene Full Name: embryonal Fyn-associated substrate

Gene ID: 10278

UniProt: O43281