EPH Receptor A3 antibody (AA 59-514) (Fluoro488)

Catalog No. ABIN7987964

The Fluoro488-conjugated Rabbit Polyclonal anti-EPH Receptor A3 antibody (ABIN7987964) specifically detects EPH Receptor A3 in FACS. The antibody is reactive with Human samples.

Quick Overview for EPH Receptor A3 antibody (AA 59-514) (Fluoro488) (ABIN7987964)

Target: EPH Receptor A3 (EPHA3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A3 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-EPH Receptor A3 Antibody (Fluoro488)

Binding Specificity: AA 59-514

Purpose: Anti-Eph receptor A3/EPHA3 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Eph receptor A3/EPHA3 recombinant protein (Position: D59-A514).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for EPH Receptor A3

Target: EPH Receptor A3 (EPHA3)

Alternative Name: EPHA3

Background:

Background: Ephrin Receptor EphA3, is also known as human embryo kinase(HEK) or Eph-like tyrosine kinase1(ETK1). Kinases that phosphorylate proteins on tyrosine residues(protein tyrosine kinases, PTKs), such as EPHA3, form a structurally related group of molecules that exhibit functional diversity. Genetic alterations that lead to the inappropriate activation or expression of PTKs may be oncogenic. Many growth factor receptors are PTKs, e.g., the receptors for epidermal growth factor(EGFR), platelet-derived growth factor(PDGFR1,PDGFR2), colony-stimulating factor-1(CSF1R), and stem cell growth factor. The EPHA3 gene is mapped to 3p11.2. Sequence comparison with other PTKs showed a high degree of homology with members of the EPH and ELK(EPHB1) families of receptor tyrosine kinases. Within axial nerves, establishment of discrete afferent and efferent pathways depends on coordinate signaling between coextending sensory and motor projections.

Gene Full Name: EPH receptor A3

Gene ID: 2042

UniProt: P29320

Pathways: RTK Signaling, Regulation of Cell Size