FRZB antibody (AA 176-325) (Cy3)

Catalog No. ABIN7991891

The Cy3-conjugated Rabbit Polyclonal anti-FRZB antibody (ABIN7991891) specifically detects FRZB in FACS. The antibody is reactive with Human samples.

Quick Overview for FRZB antibody (AA 176-325) (Cy3) (ABIN7991891)

Target: FRZB (Frizzled-Related Protein (FRZB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRZB antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-FRZB Antibody (Cy3)

Binding Specificity: AA 176-325

Purpose: Anti-FRZB Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FRZB recombinant protein (Position: E176-N325). Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for FRZB

Target: FRZB (Frizzled-Related Protein (FRZB))

Alternative Name: FRZB

Background:

Background: FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. FRZB is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. FRZB is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.

Gene Full Name: frizzled related protein

Sequence Similarities: Belongs to the secreted frizzled-related protein (sFRP) family.

Gene ID: 2487

UniProt: Q92765

Pathways: WNT Signaling, Positive Regulation of fat Cell Differentiation