FRZB antibody (AA 176-325)

Catalog No. ABIN7991900

The Rabbit Polyclonal anti-FRZB antibody (ABIN7991900) specifically detects FRZB in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for FRZB antibody (AA 176-325) (ABIN7991900)

Target: FRZB (Frizzled-Related Protein (FRZB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRZB antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Product Details anti-FRZB Antibody

Binding Specificity: AA 176-325

Purpose: Anti-FRZB Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.

Characteristics: Anti-FRZB Antibody. Tested in ELISA, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FRZB recombinant protein (Position: E176-N325). Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, -ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FRZB

Target: FRZB (Frizzled-Related Protein (FRZB))

Alternative Name: FRZB

Background:

Background: FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. FRZB is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. FRZB is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.

Gene Full Name: frizzled related protein

Sequence Similarities: Belongs to the secreted frizzled-related protein (sFRP) family.

Molecular Weight: 36 kDa

Gene ID: 2487

UniProt: Q92765

Pathways: WNT Signaling, Positive Regulation of fat Cell Differentiation