FURIN antibody (AA 591-794)

Catalog No. ABIN7991999

The Rabbit Polyclonal anti-FURIN antibody (ABIN7991999) specifically detects FURIN in WB. The antibody is reactive with Human samples.

Quick Overview for FURIN antibody (AA 591-794) (ABIN7991999)

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FURIN antibody is un-conjugated

Application: Western Blotting (WB)

Grade: Carrier-free

Product Details anti-FURIN Antibody

Binding Specificity: AA 591-794

Purpose: Anti-Furin Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human Furin shares 88% amino acid (aa) sequence identity with both mouse,rat Furin.

Characteristics: Anti-Furin Antibody. Tested in WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Furin recombinant protein (Position: T591-L794). Human Furin shares 88% amino acid (aa) sequence identity with both mouse and rat Furin.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FURIN

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Alternative Name: FURIN

Background:

Background: Furin (Fur), also known as PACE, is a protein that in humans is encoded by the FURIN gene. The protein encoded by this gene is an enzyme which belongs to the subtilisin-like proprotein convertase family. The Furin gene is located approximately 1 kb upstream of the FES gene on chromosome 15q25-q26. This gene is thought to play a role in tumor progression. Furin is one of the proteases responsible for the proteolytic cleavage of HIV envelope polyprotein precursor gp160 to gp120 and gp41 prior to viral assembly. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. Expression of furin in T-cells is required for maintenance of peripheral immune tolerance.

Gene Full Name: furin, paired basic amino acid cleaving enzyme

Sequence Similarities: Belongs to the peptidase S8 family. Furin subfamily.

Molecular Weight: 87 kDa

Gene ID: 5045

UniProt: P09958

Pathways: Notch Signaling, Neurotrophin Signaling Pathway