GGCX antibody (AA 75-730) (Fluoro594)

Catalog No. ABIN7992556

The Rabbit Polyclonal anti-GGCX antibody is suitable to detect GGCX in samples from Human and Mouse. It has been validated for FACS.

Quick Overview for GGCX antibody (AA 75-730) (Fluoro594) (ABIN7992556)

Target: GGCX (gamma-Glutamyl Carboxylase (GGCX))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GGCX antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-GGCX Antibody (Fluoro594)

Binding Specificity: AA 75-730

Purpose: Anti-GGCX Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human GGCX recombinant protein (Position: M75-A730).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for GGCX

Target: GGCX (gamma-Glutamyl Carboxylase (GGCX))

Alternative Name: GGCX

Background:

Background: Gamma-glutamyl carboxylase is an enzyme that in humans is encoded by the GGCX gene, located on chromosome 2 at 2p12. This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants.

Gene Full Name: gamma-glutamyl carboxylase

Gene ID: 2677

UniProt: P38435

Pathways: SARS-CoV-2 Protein Interactome