Gephyrin antibody (AA 148-736) (HRP)

Catalog No. ABIN7993109

The HRP-conjugated Rabbit Polyclonal anti-Gephyrin antibody (ABIN7993109) specifically detects Gephyrin in WB, IHC and ELISA. The antibody is reactive with Human, Mouse, Rat and Monkey samples.

Quick Overview for Gephyrin antibody (AA 148-736) (HRP) (ABIN7993109)

Target: Gephyrin (GPHN)

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gephyrin antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Gephyrin Antibody (HRP)

Binding Specificity: AA 148-736

Purpose: Anti-Gephyrin/GPHN Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Gephyrin/GPHN recombinant protein (Position: K148-L736).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Gephyrin

Target: Gephyrin (GPHN)

Alternative Name: GPHN

Background:

Background: Gephyrin is a protein that in humans is encoded by the GPHN gene. This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described, however, the full-length nature of all transcript variants is not currently known.

Gene Full Name: gephyrin

Gene ID: 10243

UniProt: Q9NQX3

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development