Gephyrin antibody (AA 148-736) (PE)

Catalog No. ABIN7993111

The Rabbit Polyclonal anti-Gephyrin antibody is suitable to detect Gephyrin in samples from Human, Mouse, Rat and Monkey. It has been validated for FACS.

Quick Overview for Gephyrin antibody (AA 148-736) (PE) (ABIN7993111)

Target: Gephyrin (GPHN)

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gephyrin antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-Gephyrin Antibody (PE)

Binding Specificity: AA 148-736

Purpose: Anti-Gephyrin/GPHN Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Gephyrin/GPHN recombinant protein (Position: K148-L736).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Gephyrin

Target: Gephyrin (GPHN)

Alternative Name: GPHN

Background:

Background: Gephyrin is a protein that in humans is encoded by the GPHN gene. This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described, however, the full-length nature of all transcript variants is not currently known.

Gene Full Name: gephyrin

Gene ID: 10243

UniProt: Q9NQX3

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development