Glutamate Receptor 3 antibody (Middle Region)

Catalog No. ABIN7993718

The Rabbit Polyclonal anti-Glutamate Receptor 3 antibody (ABIN7993718) specifically detects Glutamate Receptor 3 in WB. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Glutamate Receptor 3 antibody (Middle Region) (ABIN7993718)

Target: Glutamate Receptor 3 (GRIA3) (Glutamate Receptor, Ionotropic, AMPA 3 (GRIA3))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutamate Receptor 3 antibody is un-conjugated

Application: Western Blotting (WB)

Grade: Carrier-free

Product Details anti-Glutamate Receptor 3 Antibody

Binding Specificity: Middle Region

Purpose: Anti-Glutamate receptor 3/GRIA3 Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related mouse,rat sequences.

Characteristics: Anti-Glutamate receptor 3/GRIA3 Antibody. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human GRIA3, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Mouse, Rat, Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Glutamate Receptor 3

Target: Glutamate Receptor 3 (GRIA3) (Glutamate Receptor, Ionotropic, AMPA 3 (GRIA3))

Alternative Name: GRIA3

Background:

Background: Glutamate receptor 3 is a protein that in humans is encoded by the GRIA3 gene. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. It is mapped to Xq25. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. In addition to that, GRIA3 has been shown to interact with GRIP1 and PICK1.

Gene Full Name: glutamate ionotropic receptor AMPA type subunit 3

Sequence Similarities: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.

Molecular Weight: 101 kDa

Gene ID: 2892

UniProt: P42263

Pathways: PI3K-Akt Signaling, cAMP Metabolic Process, Synaptic Membrane