GDF15 antibody (AA 189-302) (Biotin)

Catalog No. ABIN7995317

The Biotin-conjugated Rabbit Polyclonal anti-GDF15 antibody (ABIN7995317) specifically detects GDF15 in WB, IHC and ELISA. The antibody is reactive with Mouse and Rat samples.

Quick Overview for GDF15 antibody (AA 189-302) (Biotin) (ABIN7995317)

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDF15 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-GDF15 Antibody (Biotin)

Binding Specificity: AA 189-302

Purpose: Anti-Gdf15 Antibody Biotin Conjugated

Predicted Reactivity: Mouse Gdf15 shares 69.1%,96.5% amino acid (aa) sequence identity with human,rat Gdf15,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Gdf15 recombinant protein (Position: S189-A302). Mouse Gdf15 shares 69.1% and 96.5% amino acid (aa) sequence identity with human and rat Gdf15, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GDF15

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Alternative Name: Gdf15

Background:

Background: Growth/differentiation factor 15 is a protein that in humans is encoded by the GDF15 gene. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation.

Gene Full Name: growth differentiation factor 15

Gene ID: 23886

UniProt: Q9Z0J7

Pathways: SARS-CoV-2 Protein Interactome